Target identification by image analysis

Pharmaceutical target identification by gene expression analysis.

The majority of newly-identified genes in the human genome show no significant sequence similarity to genes whose function is known, so they are not easily recognized as potential drug targets. Expression analysis is an alternative method to suggest possible functions of genes. We review statistical methods for gene expression analysis to identify potential pharmaceutical targets. Specifically,...

Identification of putative Arabidopsis DEMETER target genes by GeneChip analysis.

The Arabidopsis DEMETER (DME) DNA glycosylase is required for the maternal allele expression of imprinted Polycomb group (MEDEA and FIS2) and transcription factor (FWA) genes in the endosperm. Expression of DME in the central cell, not in pollen or stamen, establishes gene imprinting by hypomethylating maternal alleles. However, little is known about other genes regulated by DME. To identify pu...

Identification of Myosotis seeds by means of digital image analysis

Despite their name, the identification of seeds of Myosotis species (forget-me-not) has hitherto received little attention from archaeobotanists. In an attempt to assemble a collection of reliable identification criteria, digital image analysis was applied to photographs of Myosotis seeds by means of Fovea Pro 4.0. This program computes 23 features that describe the size and shape of the seeds ...

Stalked protozoa identification by image analysis and multivariable statistical techniques.

Protozoa are considered good indicators of the treatment quality in activated sludge systems as they are sensitive to physical, chemical and operational processes. Therefore, it is possible to correlate the predominance of certain species or groups and several operational parameters of the plant. This work presents a semiautomatic image analysis procedure for the recognition of the stalked prot...

Target Detection , Image Analysis and Modeling